DRAXIMAGE DTPA: Package Insert and Label Information (Page 2 of 4)

2.6 Radiation Dosimetry

The estimated radiation absorbed dose to various organs from an intravenous injection of Tc 99m pentetate in patients with normal and abnormal renal function is shown respectively in Table 4 and Table 5.

Table 4 Estimated Radiation Absorbed Dose for Technetium Tc 99m Pentetate Injection in Patients With Normal Renal Function Following Intravenous Injection
Absorbed Dose Per Unit Activity Administered (mcGy/MBq)
Organ Adult 15 Years 10 Years 5 Years 1 Year
Adrenals 1.4 1.8 2.7 4.0 7.2
Bone surfaces 2.4 2.9 4.3 6.1 10
Brain 0.86 1.1 1.7 2.8 4.9
Breast 0.72 0.92 1.3 2.2 4.1
Gallbladder wall 1.5 2.1 3.8 5.0 6.1
Gastrointestinal tract
Esophagus 1.0 1.3 1.9 3.0 5.4
Stomach wall 1.3 1.7 2.8 4.0 6.8
Small intestine wall 2.5 3.1 4.9 7.0 10
Colon wall 3.1 3.9 6.0 8.1 11
Upper large intestine wall 2.1 2.8 4.3 6.5 9.2
Lower large intestine wall 4.3 5.4 8.2 10 13
Heart wall 1.2 1.5 2.2 3.3 5.9
Kidneys 4.4 5.3 7.5 11 18
Liver 1.2 1.6 2.5 3.8 6.4
Lungs 1.0 1.3 2.0 3.0 5.5
Muscles 1.6 2.0 3.0 4.3 6.8
Ovaries 4.2 5.3 7.7 10 13
Pancreas 1.4 1.8 2.8 4.3 7.4
Red marrow 1.5 1.8 2.7 3.7 5.7
Skin 0.87 1.0 1.7 2.6 4.4
Spleen 1.3 1.6 2.6 3.9 6.8
Testes 2.9 4.0 6.8 9.4 13
Thymus 1.0 1.3 1.9 3.0 5.4
Thyroid 1.0 1.3 2.1 3.3 6.0
Urinary bladder wall 62 78 110 150 170
Uterus 7.9 9.6 15 18 22
Remaining organs 1.7 2.1 3.0 4.2 6.6
Effective dose per unit activity(mcSv/MBq) 4.9 6.3 9.4 12 16
Table 5 Estimated Radiation Absorbed Dose for Technetium Tc 99m Pentetate Injection in Patients With Abnormal Renal Function Following Intravenous Injection
Absorbed Dose Per Unit Activity Administered (mcGy/MBq)
Organ Adult 15 Years 10 Years 5 Years 1 Year
Adrenals 4.1 5.1 7.6 11 21
Bone surfaces 6.0 7.1 11 15 28
Brain 2.8 3.5 5.7 9.1 16
Breast 2.3 3.0 4.2 6.8 13
Gallbladder wall 4.2 5.7 9.2 13 16
Gastrointestinal tract
Esophagus 3.3 4.2 6.2 9.6 17
Stomach wall 3.8 5.0 7.9 11 19
Small intestine wall 4.5 5.6 8.5 13 22
Colon wall 4.5 5.8 8.7 13 22
Upper large intestine wall 4.3 5.6 8.1 13 21
Lower large intestine wall 4.9 6.1 9.5 13 23
Heart wall 3.7 4.7 7.0 10 18
Kidneys 7.7 9.2 13 19 32
Liver 3.7 4.6 7.1 11 19
Lungs 3.3 4.2 6.2 9.5 17
Muscles 3.2 4.0 6.1 9.1 17
Ovaries 5.0 6.2 9.2 14 23
Pancreas 4.3 5.3 8.0 12 21
Red marrow 3.4 4.2 6.4 9.3 16
Skin 2.2 2.6 4.2 6.7 12
Spleen 3.8 4.7 7.3 11 19
Testes 3.5 4.5 6.9 10 18
Thymus 3.3 4.2 6.2 9.6 17
Thyroid 3.4 4.2 6.7 11 19
Urinary bladder wall 21 27 39 50 66
Uterus 6.1 7.4 11 16 25
Remaining organs 3.3 4.1 6.3 9.7 17
Effective dose per unit activity(mcSv/MBq) 4.6 5.8 8.7 13 21

The estimated radiation absorbed dose to various organs from the inhalation of Tc 99m Pentetate Injection is shown in Table 6.

Table 6 Estimated Radiation Absorbed Dose for Technetium Tc 99m Pentetate Injection Administered by Inhalation
Absorbed Dose Per Unit Activity Administered (mcGy/MBq)
Organ Adult 15 Years 10 Years 5 Years 1 Year
Adrenals 2.1 2.9 4.4 6.7 12
Bone surfaces 1.9 2.4 3.5 5.3 9.8
Breast 1.9 1.9 3.3 4.8 7.8
Gastrointestinal tract
Stomach wall 1.7 2.2 3.5 5.1 8.9
Small intestine wall 2.1 2.6 4.1 6.3 11
Upper large intestine wall 1.9 2.4 3.8 6.1 10
Lower large intestine wall 3.2 4.2 6.3 8.8 15
Kidneys 4.1 5.1 7.2 11 19
Liver 1.9 2.5 3.7 5.5 9.7
Lungs 17 26 36 54 100
Ovaries 3.3 4.1 6.1 8.9 15
Pancreas 2.1 2.6 4.0 6.1 11
Red marrow 2.7 3.4 4.7 6.2 9.6
Spleen 1.9 2.4 3.6 5.6 9.9
Testes 2.1 3.1 5.2 7.9 15
Thyroid 0.99 1.7 2.7 4.4 7.8
Urinary bladder wall 47 58 84 120 230
Uterus 5.9 7.2 11 16 27
Other tissue 1.8 2.2 3.2 4.9 8.6
Effective dose per unit activity(mcSv/MBq) 5.9 8.0 11 17 31

DrugInserts.com provides trustworthy package insert and label information about marketed drugs as submitted by manufacturers to the US Food and Drug Administration. Package information is not reviewed or updated separately by DrugInserts.com. Every individual package label entry contains a unique identifier which can be used to secure further details directly from the US National Institutes of Health and/or the FDA.

As the leading independent provider of trustworthy medication information, we source our database directly from the FDA's central repository of drug labels and package inserts under the Structured Product Labeling standard. Our material is not intended as a substitute for direct consultation with a qualified health professional.

Terms of Use | Copyright © 2022. All Rights Reserved.